德国科隆大学招收系统生物学博士后

POSTDOCPOSITIONINSYSTEMSBIOLOGYAVAILABLE

In the groups of
Michael Lässig, Institute for Theoretical Physics
and
Björn Schumacher,CECAD-Cluster of Excellence in Aging Research
at the
University of Cologne

Sybacol: The Systems Biology of Ageing Cologne (Sybacol) consortium brings together biologists, physicists, and clinicians at the University of Cologne to develop novel integrated approaches to unravel the mechanisms of ageing.
Institution information: Institute for Theoretical Physics, University of Cologne, Zülpicher Str. 77, 50937 Cologne andCECADCologne Cluster of Excellence: Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Zülpicher Str. 47a, 50674 Cologne, Germany
Location: Cologne is a vibrant city with a highly international academic research environment.
Website:http://www.thp.uni-koeln.de/~lassig/,www.uni-koeln.de/inter-fak/cecad/schumacher,http://www.sybacol.org/.
Summary: Our research aims at understanding the mechanisms that underlie the ageing process. We are developing novel approaches to investigate the complex, interacting pathways that regulate longevity from a systems biology perspective.
Job description: We are seeking a highly motivated Postdoc candidate who will conduct analysis of novel large scale datasets, and develop systems biology models of ageing pathways. This may include regulatory network analysis, statistics and dynamics of gene expression, somatic evolutionary dynamics, as well as development of statistical methods and algorithms.
Qualification: Applicants should have a solid background in computational biology, bioinformatics, or statistical physics and hold a PhD in physics, mathematics, informatics, biology or related disciplines. Postdoc candidates should have demonstrated intellectual independence and outstanding performance by their publication record.
How to Apply: Please send your application in a single pdf containing CV, letter of intent, names and addresses of three references to Christa Stitz (cstitz@uni-koeln.de) by September 15, 2012.
Selected Publications:
Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, MullendersLHF, van der HorstGTJ, Brüning JC, Niessen CM, HoeijmakersJHJand Schumacher B. Persistent transcription-blockingDNAlesions trigger somatic growth attenuation associated with longevity. Nature Cell Biol. 2009 May;11(5):604-15.
Schumacher B, van der Pluijm I, Moorhouse MJ, Rasile Robinson A, Suh Y, Breit TM, van Steeg H, Niedernhofer LJ, van Ijcken W, Bartke A, Spindler SR, HoeijmakersJHJ, van der HorstGTJand Garinis GA. Delayed and accelerated aging share common longevity assurance mechanisms. PLoS Genet. 2008 Aug 15;4(8):e1000161.
Schumacher B, Hanazawa M, Lee M, Nayak S, Volkmann K, Hofmann R, Hengartner M, Schedl T, Gartner A. Translational Repression of C. elegans p53 byGLD-1 regulatesDNAdamage induced apoptosis. Cell, 11 February 2005; 120: 357-368.
L. Perfeito, S. Ghozzi, J. Berg, K. Schnetz, M. Lässig, Nonlinear fitness landscape of a molecular pathway, PloS Genetics 7, e1002160 (10 pages), (2011).
M. Luksza, M. Lässig, and J. Berg, Significance analysis and statistical mechanics: an application to clustering, Phys. Rev. Lett. 105, 220601 (2010).
J. Berg and M. Lässig, Local graph alignment and motif search in biological networks, Proc. Natl. Acad. Sci. 101, 14689, (2004).