英国曼彻斯特大学帕特森癌症研究所招博士后

Postdoctoral Scientist – Molecular Oncology

• Reference number: PI/12/44
• Salary in the range of £28,500 – £38,000 (dependent upon qualifications and experience)
• Three year fixed-term contract

The Paterson Institute for Cancer Research, an Institute of The University of Manchester, is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK, the largest independent cancer research organisation in the world. Our aim is to understand the fundamental basis of cancer and apply that knowledge to developing new treatment strategies for cancer patients. Our advanced research programmes span a spectrum of cancer research, from the molecular and cellular basis of cancer through to drug discovery, translational research and clinical trials. The Institute has outstanding laboratory facilities and exceptional core services, including next generation sequencing, microarrays, confocal microscopy, bioinformatics, histology and mass-spectrometry. We are situated in Manchester, England, a vibrant and dynamic city that is surrounded by beautiful countryside and has excellent transport links both nationally and internationally.

We seek an ambitious postdoctoral scientist to join the Molecular Oncology Group on a three year Kay Kendall Leukaemia Fund supported position. We recently demonstrated that the drug nilotinib drives paradoxical activation of theRAF/ERKsignaling pathway in drug-resistant chronic myeloid leukaemia (CML) cells to provide a survival advantage (seeCancer Cell2011,20: 294), and the successful candidate will study the biological and clinical significance of these findings.

The successful candidate will hold a PhD in cell biology, biochemistry, or a relevant field, and have prior experience in leukaemia, biochemistry, molecular biology, cell biology and mass-spectrometry. They will have excellent laboratory, analytical and presentation skills, and will work closely with other group members using a variety of additional approaches, including next generation sequencing, molecular pathology, and transgenic and other in vivo models (see Cancer Cell 2009,15: 294; Cell 2010,140, 209; Cancer Cell 2011,19: 45; New England Journal of Medicine 2012,366: 207; Genome Research 2012, 22: 196). Access to patient samples is available through theMCRCBiobank, located at the Paterson Institute.

Informal enquiries should be directed to Professor Richard Marais:rmarais@picr.man.ac.uk

To apply for this position please visit our website:www.paterson.man.ac.uk

For applicants who are unable to download this information from our website, please contact HR department on 0161 446 3231, email:jobs@picr.man.ac.ukto have this information sent by post.

The deadline for receipt of applications is 24th August 2012 and first round interviews will take place during the weeks commencing 3rd September 2012.