瑞典卡罗林斯卡医学院肿瘤生物学博士后职位

Karolinska Institutet

invites applications for a

Postdoc position in Breast Cancer Cell Biology

Department of Biosciences and Nutrition

Area of responsibilities/description of the work
Description of the research project/area of research
Breast cancer displays a marked histological and functional heterogeneity. In vitro studies suggest that this may be explained by stochastic state transitions causing plasticity among cultured breast cancer cells. However, it is unclear how plasticity may occur or be regulated in vivo. To address this issue, an established in vivo transplantation model of breast cancer where primary breast tumors are directly propagated in vivo will be used. The project aim is to establish xenograft models of different morphological breast cancer subtypes and to investigate their plasticity and response to various treatments. Methods to be used also include FACS-sorting, cell culture in vitro, gene expression profiling, bioinformatics, standard molecular cell biology techniques, and statistical modeling in collaboration with biostatisticians.

The project will be performed as a collaboration between professors Rune Toftgård and Staffan Strömblad, Center for Biosciences, Department of Biosciences and Nutrition, KI, and is financed by and integrated with the Karolinska Institutet Breast Cancer Theme Center (BRECT), where leading basic, translational and clinical breast cancer researchers collaborate closely together.
Start date: as soon as possible.

Qualifications
We are searching for a strongly dedicated candidate with an excellent track record in cancer biology, cell and molecular biology, experimental pathology, or similar fields. Experience with mouse models, histopathology, FACS-sorting, expression profiling, and statistical modeling will be an advantage. Excellent communication skills in English are required.

Special weight will be put on academic skills and demonstrated excellence in research.
Duration: 2 years with a possibility for extension.

Dependent on the background of the successful applicant, the succesful candidate will be supported either by a scholarship or an employment.

A person is eligible for a postdoc position if he or she has obtained a PhD no more than five years before the last date of employment as postdoc.

Form of employment:
Temporary

Contact persons:

Rune Toftgård, Professor
phone: +46-8-524 810 53
rune.toftgard@ki.se

Staffan Strömblad, Professor
phone: +46-8-524 811 22
staffan.stromblad@ki.se

Trade union representatives:

Joseph Rafter, SACO
phone:+46-8-524 835 45
joseph.rafter@ki.se

Gunnar Stenberg, SEKO
phone: +46-8-524 880 75
gunnar.stenberg@ki.se

Christina Thulin Andersson, OFR
phone: 46-8-524 811 79
christina.thulin-andersson@ki.se

Please send your application, marked with reference number 1475/2012, to reach us by no later than April 3 2012 to Karolinska Institutet, Institutionen för Biovetenskaper och Näringslära, Eva Nordlander, Novum 141 83 Huddinge or toeva.nordlander@ki.se. The following documents must be submitted with your application, and written in English:
-Introduction letter
-CV
-A synopsis of current research work
-PhD Degree certificate or a formal document from the dissertation committee stating the date of dissertation.
-Three letters of reference

See Karolinska Institutet´s homepage athttp://ki.se/qualificationsportfoliofor information about the qualification portfolio.

Please note that one copy of all documents will be kept by the college for a period of two years, in accordance with a directive from the National Archives. Published material submitted for review is excepted from this rule.

Karolinska Institutet aims to promote equal opportunities by encouraging a balanced gender distribution. We also value the qualities that ethnic and cultural diversity can contribute to the university.

The Department of Biosciences and Nutrition performs research and education in areas of medical science including molecular endocrinology, cancer biology, functional genomics, systems biology, epigenetics, structural biochemistry, cellular virology, and nutrition.www.bionut.ki.se

Karolinska Institutet is one of the world´s leading medical
universities. Its mission is to contribute to the improvement of human health through research and education. Karolinska Institutet accounts for over 40 per cent of the medical academic research conducted in Sweden and offers the country´s broadest range of education in medicine and health sciences. Since 1901 the Nobel Assembly at Karolinska Institutet has selected the Nobel laureates in Physiology or Medicine.