比利时VIB研究所人类遗传学中心博士后岗位

Postdoctoral Position : Belgium
Employer: VIB
Location: Herestraat 49, 3000 Leuven, BELGIUM, Belgium
Type: Other
Posted: November 20, 2011
Expires: February 29, 2012
Requisition number: Euraxess-euraxess-jobs-33750409

job description

The Center for Human Genetics at the VIB research institute and the University of Leuven (K.U.Leuven, Belgium) is looking for a motivated postdoctoral researcher to study the molecular genetics and biology of leukemia.
Description

The laboratory of Prof. Jan Cools has a major interest in the molecular genetics of hematological malignancies. Past projects have identified and characterized novel oncogenes that contribute to the development of leukemia. We use various genetic tools to study cancer genomes, and use cell-based as well as mouse models for the functional characterization of identified oncogenes and as pre-clinical models. We are currently using next-generation sequencing (exome sequencing, full genome sequencing, RNA-seq) to study leukemia genomes, and have identified a large number of novel aberrations. In the next years, we want to expand our genetic analysis and start in-depth functional analyses on several of these new oncogenes to determine their exact role in leukemogenesis. To strengthen our research team, we are looking for a motivated postdoctoral fellow with experience in genetics and cell biology. References to previous work: Lahortiga I, et al. (2007). Duplication of the MYB oncogene in T-cell acute lymphoblastic leukemia. Nature Genetics, 39:593-595. De Keersmaecker K, et al. (2008). Kinase activation and transformation by NUP214-ABL1 is dependent on the context of the nuclear pore. Molecular Cell, 31:134-142. Kleppe M, et al. (2010). Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia. Nature Genetics, 42:530-535. Kleppe M, et al. (2011). PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia. Blood, 117:7090-7098.
Benefits

We offer a postdoctoral position for three years in an international research institute in the center of Europe (close to Brussels), with access to high end technology, core facilities, and technical support. The starting date is between April and October 2012.中国 （海归人才网）//www.baticalc.com为广大海外高层次人才提供回国就业、创业机会，关注海归生活。高层次人才就业QQ群：106247053 微博：http://weibo.com/liuxuehr