法国巴黎巴斯德研究所肿瘤生物学博士后职位

Two postdoctoral positionsare available immediately in the Lymphocyte Development & Oncogenesis Laboratory at the Institut Pasteur Paris to work on ambitious projects aiming to decipher the mechanisms and pathways leading to genome instability and tumor development in B and T lymphocytes.

Research Keywords:Cancer, Immunology, Mouse models, Lymphocyte development, Genomics, Genome integrity,DNArepair,DNAdamage

Projects outline:Lymphoid cancers are among the most common human malignancies and characteristically harbor genomic aberrations. We are interested in developing experimental approaches that would provide an understanding of how and which genomic aberrations underlie tumor genesis. It has become apparent that the generation ofDNAdouble strand breaks (DSB) during the programmed process of antigen receptor diversification, including RAG1/2 protein-generatedDNAbreaks during V(D)J recombination, are key common intermediates in the appearance of lymphoid neoplasm. We have created a series of mouse models carrying aberrant V(D)J recombination leading to the rapid development of lymphoid tumors, reminiscent of human malignancies. In this project, we aim to elucidate the molecular mechanisms, the genomic lesions and the oncogenic pathways underlying B and T cell cancers using a combination ofgermline and non-germline genetically engineered mouse modelsandcutting-edge genomic, transcriptomic and computational technologies.

Candidate requirements:Candidates should be highly motivated by cancer biology, cancer genomics and genome integrity research fields and be willing to take on intellectual, scientific and technical challenges. The applicant should have a record of delivering high quality research and strong experience in the subjects of cancer, immunology, genomics, mouse models, or lymphoma and leukemia. Experience in transcriptomic and genomic analysis and/or computational biology would be desirable. Preference will be given to candidates with less than two years of experience after his/her Ph.D.

To apply:Applicants should send a cover letter with a brief statement of research experience, technical expertise and interests, a C.V., a list of publications and three references to Ludovic Deriano (ludovic.deriano@pasteur.fr)