美国爱荷华大学神经系统科学与新陈代谢博士后

Job Description

A postdoctoral or visiting scholar position will be available from early 2012 at the University of Iowa Carver College of Medicine and the Eagles Diabetes Research Center to investigate the neural control of feeding behavior and etiological mechanisms of obesity and eating disorders, such as anorexia nervosa, in genetic mouse models. Hypothalamic AgRP neurons are critical for regulation of feeding and body weight, as acute ablation of these cells in adult mice leads to anorexia and profound weight loss (see attached Review Article: Wu & Palmiter, Eur. J. Pharmacol., 2011). We demonstrated that such anorexic phenotype is fully reversible with the aid of a GABA-A receptor agonist and that GABA release from AgRP neurons onto neurons in the lateral parabrachial nucleus (PBN) is essential for maintenance of appetite and body weight (Wu et al., Cell, 2009). Therefore, we proposed that a novel hindbrain circuit and associated signaling pathways underlie neural adaptive control of anorexia and obesity through bi-directional modulation. This newly established laboratory is fully funded and well equipped, which permits utilization of cutting-edge technologies including, conditional gene targeting, viral-based gene transfer, immunocytochemistry, in vivo and ex vivo electrophysiology, functional profiling of novel drug targets, and CLAMS system-based metabolic and behavioral analysis. In addition, the University of Iowa Carver College of Medicine has outstanding core research (microscopy & imaging, histopathological, genomic, proteomic and transgenic) facilities, for the rapid advancement of research work. The ideal candidate will be a recent PhD and/or MD with a strong background in molecular biology and physiology. Knowledge of pharmacology, biochemistry, microbiology, electrophysiology, behavioral neurobiology, as well as experience with rodents would be an added advantage. The University of Iowa is an Equal Opportunity/Affirmative Action employer. Women and minorities are encouraged to apply. See below the ranking info of US Medical Schools for Research: http://grad-schools.usnews.rankingsandreviews.com/best-graduate-schools/top-medical-schools/research-rankings/page+2 To apply send your CV with publication list, statement of research interests, and name & contact info of three referees to Dr. Qi Wu at qiwu@uw.edu

Contact:

Qi Wu Pharmacology University of Iowa Iowa City, IA 52242 United States Email:qiwuuw.edu

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