法国IGBMC研究所细胞生物学和转化医学方向博士后

Postdoctoral position in Cell Biology and Translational Medecine : Strasbourg, France
Employer: IGBMC
Website:http://www-igbmc.u-strasbg.fr...
Location: Strasbourg, France
Type: Postdoctoral
Posted: September 08, 2011
Expires: November 07, 2011
Jobs by tag(s): postdoctoral membrane traffic organelle muscle myopathy translational medecine
Requisition number: Postdoctoral position Laporte's team

job description

Intracellular organization and dynamics in skeletal muscle under normal and pathological conditions

The regulation of the intracellular organization of skeletal muscle is poorly understood. We study rare and severe neuromuscular disorders caused by mutations in proteins affecting organelles and membrane trafficking. Our team has identified the myotubularin family of phosphoinositide phosphatases mutated in several neuromuscular disorders including myopathies and peripheral neuropathies, and has recently involved the amphiphysin-dynamin complex in similar diseases.
While focusing on these genetic diseases, our approaches are multidisciplinary and encompass the identification of the implicated genes by next generation sequencing, the study of the molecular and cellular functions of these proteins in cells and in C. elegans, the validation of mammalian disease models, and the use of viral vectors (AAVs) for pathophysiology studies and preclinical therapeutic trials. In parallel, we study the function of these proteins in skeletal muscle through the development of imaging methods (correlative microscopy and in vivo imaging) in close contact with our institutional platforms.

The *candidate *will contribute to characterize the cellular roles of myotubularins, amphiphysin and dynamin on membrane and organelle trafficking in muscle cells and tissues, both under normal and pathological conditions. Candidates must be highly motivated and have a PhD in molecular or cellular biology. A background in cell biology will be an asset. French speaking is not a requirement.

The *IGBMC *institute is one of the leading European centres of biomedical research located in Strasbourg’s science park in France. We have excellent funding and core facilities, which include on-site transgenic services and in-house Next Gen sequencing, antibody production, and confocal/electron imaging together with bioinformatics, structural biology and microarray platforms. Scientists from more than 40 countries work at the IGBMC. Strasbourg is an international and cosmopolitan city, with a very nice countryside, close to Germany and 2 hours from Paris by train.

Please send your application, curriculum vitae and 2-3 referees addresses by email to : Sylviane Bronner (Sylviane.BRONNER@igbmc.fr;http://www-igbmc.u-strasbg.fr/Laporte: lab of Jocelyn Laporte)

Selection of our recent publications:
-Fugier et al. Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy. Nat Med. 2011 Jun;17(6):720-5.
-Hnia et al. Myotubularin controls desmin intermediate filament architecture and mitochondrial dynamics in human and mouse skeletal muscle. J Clin Invest. 2011 Jan 4;121(1):70-85.
-Cowling et al. Increased expression of wild-type or a centronuclear myopathy mutant of dynamin 2 in skeletal muscle of adult mice leads to structural defects and muscle weakness. Am J Pathol. 2011 May;178(5):2224-35.
-Al-Qusairi et al. Defective excitation-contraction coupling in muscle fibres lacking myotubularin phosphoinositide phosphatase. Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18763-8.
-Nicot and Laporte “Endosomal phosphoinositides and human diseases”. Traffic. 2008 Aug;9(8):1240-9. Review
-Nicot et al. Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. Nat Genet. 2007 Sep;39(9):1134-9.

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