> > 海外>

美国加州Buck老年病研究中心诚聘肾结石研究博士

2011-08-15 10:53 来源: 未知 作者: 颜墨

job description

Postdoctoral position – Kapahi & Stoller Laboratories

A model for studying kidney stone formation and drug screening in Drosophila.

Dr. Stoller is one of the leading experts in the field of human kidney stones. The focus of the Kapahi Laboratory is to identify and characterize the genetic pathways that mediate effects on lifespan and age-related diseases.

Recently, the Kapahi and Stoller laboratories have developed a model for kidney stones using D. melanogaster. Kidney stones (nephrolithiasis) account for more than $2.1 billion in medical expenditures annually in the United States 8. Symptomatic kidney stones are a source of severe pain, infection, morbidity and mortality. Furthermore, patients with urinary stone disease have an increased likelihood of developing cardiovascular disease and are more likely to express symptoms of metabolic syndrome. The calcification process underlying early stone formation may be a common linkage between these systemic disorders. We observe that the formation of mineralized concretions in the fly Malpighian tubule (‘kidney’) is strikingly similar to the early stages of human stone development. Consequently, understanding the genetic and environmental modulators of concretion formation in Drosophila might provide (1) fundamental insights into the formation of human stones, (2) a better understanding of the linkage between nephrolithiasis and other human diseases and (3) a screening too for developing new kidney stone medications. In addition and at even more fundamental level, this research might help uncover the role of nutrition in the etiology of age-related human diseases including kidney stones, diabetes and cardoiovascular diseases. Candidates with interest or experience in Drosophila model systems are strongly encouraged to apply.

Selected publications:
1. Vargas M, Yamaguchi A, Luo N, Kapahi P. The role of S6 Kinase and serotonin in maintaining nutrient balance in D. melanogaster. Current Biology.
2. Kapahi P, Rogers A, Chen D. Katewa SD, Li P, Kockel L. ‘WithTOR, less is more: The emerging role of theTORpathway in aging.’ Cell Metabolism
3. Zid BM, Rogers A, Katewa SD, Au Lu T, Benzer S, Kapahi P. 4E-BP modulates lifespan and mitochondrial translation upon dietary restriction in Drosophila. Cell (2009).
4. Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, & Benzer S. Regulation of lifespan in Drosophila by modulation of genes in theTORsignaling pathway. Curr Biol. 2004

The Buck Institute for Age Research in Novato is located 20 miles north of San Francisco & Berkeley. The Buck Institute is the only independent institute in the U.S. devoted solely to research on aging and age-related diseases. Our mission is to increase the healthspan, the healthy years of life. Awarded a federal grant to establish interdisciplinary research in a new field called Geroscience, Buck scientists work in a unique, collaborative environment that allows scientists to initiate studies quickly and respond to new opportunities in fields such as stem cell research and regenerative medicine. The Buck Institute has excellent in-house proteomic, genomic and microscopy facilities. Our scientists represent a variety of complementary fields, including genetics, epigenetics, biochemistry, molecular biology, bioenergetics, age-associated disease; and technological disciplines such as genomics, proteomics, protein interaction networks and bio-informatics. The Buck Institute has an excellent postdoctoral research program. For more information visithttp://www.buckinstitute.org.

The candidate must be a US citizen and will receive training in specific area(s) of research with the aim of progressing towards a career as independent investigator.

For more information regarding this position please submit your CV & cover letter mentioning the* Kapahi & Stoller Laboratories* to:jvankampen@buckinstitute.org

    声明:凡本网注明"来源:XXX"的文/图等稿件,本网转载出于传递更多信息及方便产业探讨之目的,并不意味着本站赞同其观点或证实其内容的真实性,文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用,须保留本网站注明的“来源”,并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜,请与我们联系。

    海归QQ群

    申请加群请以“留学国家-目前所在地”格士发送请求,群有人数上限,每人只能加一个群。
    海归部落千人群
    63984971
    海归部落2号群
    103237942
    上海海归人才2号群
    461068872
    北京海归人才群
    63984971
    上海海归人才群
    103237942
    天津海归人才群
    461068872
    重庆海归人才群
    172719654
    山东海归人才群
    462302845
    江苏海归人才群
    172331746
    浙江海归人才群
    314125833
    江西海归人才群
    463247306
    福建海归人才群
    457497619
    安徽海归人才群
    457823891
    河南海归人才群
    264015004
    湖北海归人才群
    109623634
    湖南海归人才群
    458690950
    广东海归人才群
    432013578
    海南海归人才群
    312160331
    黑龙江海归人才群
    312929192
    吉林海归人才群
    313316571
    辽宁海归人才群
    109899038
    河北海归人才群
    282994183
    陕西海归人才群
    315357786
    甘肃海归人才群
    315753165
    宁夏海归人才群
    517762915
    青海海归人才群
    319457961
    四川海归人才群
    517765170
    云南海归人才群
    432350311
    贵州海归人才群
    517766496
    广西海归人才群
    517767217

    Baidu
    map