Job Description
Two postdoctoral fellow positions are available immediately in the Department of Molecular Pharmacology and Therapeutics at Loyola University Chicago Stritch School of Medicine. The current focus of the laboratory is to elucidate the signaling pathways that regulate various cellular events in neurodegenerative disorders (like Parkinson’s and Alzheimer’s disease) and cancer. The primary responsibilities for these positions will be to elucidate (in depth) the role of MAPK pathways, in particular, Mixed Lineage Kinases in Parkinson’s disease (PD), using both cellular and animal models. The laboratory is equipped with state-of-the art equipments and employs the latest molecular biology, cell biology, biochemical methods and animal models to address the various on-going projects. The Institution offers a highly interactive cancer and neuroscience research environment and access to core facilities to perform any cutting-edge techniques and fully equipped state-of-the-art animal facility. The premiere location of Stritch School of Medicine (only 15 miles west of downtown Chicago) provides many opportunities of collaboration with other Universities and research Institutions around Chicago. There are affordable housings available in the safe, beautiful suburbs of Chicago, not far from the medical campus.
Ideal candidates should have a Ph.D. degree with relevant publications in biochemistry, molecular or cellular biology and demonstrated expertise in animal models of disease and microscopy. Ability to work in a competitive environment, demonstrated creativity and independence, and high motivation are strongly desirable.
Selected References:
1) Sathyanarayana P, Barthwal MK, Kundu CN, Lane ME, Bergmann A, Tzivion G, Rana A. Activation of drosophila MLK by Ceramide, reveals TNF-alpha and Ceramide as agonists of mammalian MLK3. Mol. Cell. 2002 Dec; 10(6):1527-33.
2) Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, Pradeep A, Sharma C, Woodgett JR, Rana A. Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival. J Biol Chem. 2003 Feb 7; 278(6):3897-902.
3) Mishra R, Barthwal MK, Sondarva G, Rana B, Wong L, Chatterjee M, Woodgett JR, Rana A. Glycogen synthase kinase 3beta induces neuronal cell death via direct phosphorylation of mixed lineage kinase 3. J Biol Chem. 2007 Oct 19; 282(42):30393-405
4) Velusamy Rangasamy, Rajakishore Mishra, Suneet Mehrotra, Gautam Sondarva, Rajarshi S. Ray, Arundhati Rao, Malay Chatterjee, Basabi Rana and Ajay Rana. Estrogen Negatively Regulates the Pro-apoptotic Function of Mixed Lineage Kinase 3 in Estrogen Receptor Positive Breast Cancer. Cancer Research, 2010 Feb 15; 70 (4):1731-40.
5) Gautam Sondarva, Chanakya N. Kundu, Suneet Mehrotra, Rajakishore Mishra, Velusamy Rangasamy, Pradeep Sathyanarayana, Rajarshi S. Ray, Basabi Rana and Ajay Rana. TRAF2-MLK3 interaction is essential for TNF-α-induced MLK3 activation. Cell Research, 2010 Jan; 20(1):89-98.
6) Kanthasamy A, Jin H, Mehrotra S, Mishra R, Kanthasamy A, Rana A. Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: Relevance to oxidative stress and neuroinflammation in Parkinson's disease. Neurotoxicology, 2010 Sep; 31 (5): 555-61.
7) Jin H, Kanthasamy A, Anantharam V, Rana A and Kanthasamy A. Transcriptional regulation of pro-apoptotic protein kinase C-delta: implication for oxidative stress-induced neuronal cell death J. Biol. Chem. 2011 Jun 3; 286 (22):19840-59
Please send curriculum vitae and the names of three references to:
Prof. Ajay Rana, Ph.D.
Loyola University Medical Center
Department of Molecular Pharmacology
Bldg. 101, Room 2700
2160 South First Avenue,
Maywood, IL 60153. USA
Email: arana@lumc.edu
Tel: 708-216-5761; Fax: 708-216-6596
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