> > 海外>

英国曼彻斯特Paterson肿瘤研究所招聘免疫学博士后

2011-06-15 16:48 来源: 未知 作者: admin

Employer: Paterson Institute for Cancer Research
Website:http://www.paterson.man.ac.uk
Location: Manchester, United Kingdom
Type: Postdoctoral
Posted: June 13, 2011
Expires: July 18, 2011
Jobs by tag(s): paterson institute for cancer research postdoctoral scientist immunology manchester united kingdom cell biology biological sciences microbiology paterson institue for cancer reseach cruk postdoctoral immunology molecular biology biochemistry animal models
Requisition number: PI / 11 / 16
Science jobs from Paterson Institute for Cancer Research: job description

Postdoctoral Scientist – Immunology

• Job Ref: PI/11/16
• 3 year fixed-term position
• Salary in the range of £28,500 – £38,000 dependent upon qualifications and experience

The Paterson Institute is a leading cancer centre of excellence core-funded by Cancer Research UK and is an Institute of The University of Manchester.

We have established that the 5T4 glycoprotein is required for optimal functional cell surface expression of the chemokine receptor CXCR4 and CXCL12 mediated chemotaxis in mouse embryonic cells (1). We have now shown that in some human tumour cells, 5T4 expression is necessary for CXCR4/CXCL12 chemotaxis. The regulation of functional chemokine receptor expression associated with 5T4 molecules is a means to control different biological responses to the chemokine CXCL12 advantaging the growth and spread of a 5T4 positive tumour from its primary site. Such a possibility is consistent with data from a retrospective gene expression profiling of diagnostic B-ALL bone marrow samples which revealed significantly higher 5T4 transcript levels were associated with a subset of patients with high risk of relapse. A key goal is to define the mechanisms regulating the expression of 5T4 in this lineage and its biological consequence in vitro and in vivo. This will begin with microarray and/or proteomic comparisons of naturally 5T4+ and –ve sub-lines of established B-ALL lines. Xenograft models are available to investigate the role of 5T4 molecules in tumour spread in vivo (2). The wider goal is to define the 5T4 dependent biological responses controlling normal and tumour cell function.

You should preferably have a strong background in molecular biology, biochemistry and animal models.

Informal enquires to Peter L Stern,pstern@picr.man.ac.ukor tel: 0161 446 3127

1. Southgate, TD, McGinn OJ, Castro FV, Rutkowski AJ, , Al-Muftah M, Marinov G, Smethurst GJ, Shaw D, Ward CM, Miller CJ, and Stern PL. (2010). CXCR4 Mediated Chemotaxis is Regulated by 5T4 Oncofetal Glycoprotein in Mouse Embryonic Cells. PLoS ONE 5(4): e9982. doi:10.1371/journal.pone.0009982.
2. Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V. RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia. Blood. 2011 May 23. [Epub ahead of print]

To apply for this position please visit our website:http://www.paterson.man.ac.uk

For applicants who are unable to download this information from our website, please contact HR department on 0161 446 3231, email:jobs@picr.man.ac.ukto have this information sent by post.

Closing date: 18th July 2011.

    声明:凡本网注明"来源:XXX"的文/图等稿件,本网转载出于传递更多信息及方便产业探讨之目的,并不意味着本站赞同其观点或证实其内容的真实性,文章内容仅供参考。如其他媒体、网站或个人从本网站转载使用,须保留本网站注明的“来源”,并自负版权等法律责任。作者如果不希望被转载或者联系转载等事宜,请与我们联系。

    海归QQ群

    申请加群请以“留学国家-目前所在地”格士发送请求,群有人数上限,每人只能加一个群。
    海归部落千人群
    63984971
    海归部落2号群
    103237942
    上海海归人才2号群
    461068872
    北京海归人才群
    63984971
    上海海归人才群
    103237942
    天津海归人才群
    461068872
    重庆海归人才群
    172719654
    山东海归人才群
    462302845
    江苏海归人才群
    172331746
    浙江海归人才群
    314125833
    江西海归人才群
    463247306
    福建海归人才群
    457497619
    安徽海归人才群
    457823891
    河南海归人才群
    264015004
    湖北海归人才群
    109623634
    湖南海归人才群
    458690950
    广东海归人才群
    432013578
    海南海归人才群
    312160331
    黑龙江海归人才群
    312929192
    吉林海归人才群
    313316571
    辽宁海归人才群
    109899038
    河北海归人才群
    282994183
    陕西海归人才群
    315357786
    甘肃海归人才群
    315753165
    宁夏海归人才群
    517762915
    青海海归人才群
    319457961
    四川海归人才群
    517765170
    云南海归人才群
    432350311
    贵州海归人才群
    517766496
    广西海归人才群
    517767217

    Baidu
    map